It’s Never Only a Sore Throat
One of the most common encountered conditions that I see is pharyngitis (sore throat). Pharyngitis accounts for approximately 12 million annual visits to offices per year. Thus, the likelihood is that a primary care provider will see their share of pharyngitis.
The purpose of this post is not to give the typical background, etiology and treatment options for adult pharyngitis but for people to consider some alternative causes and avoid the “it’s ‘only’ a sore throat” mantra.
Sore throats can be caused by infectious agents such as viruses and bacteria and by non-infectious conditions such as reflux of acid from the stomach. If the treatable bacterial forms of pharyngitis are not properly addressed, patients can develop issues with their kidneys, arthritis, tonisllar abscesses and even potentially lethal blood clots.
Many people are familiar with the term, “strep throat.” Indeed, group A streptococcus (GAS) is one of the more common bacterial pathogens responsible for causing a sore throat. There is even a rapid strep test which can be performed and resulted in as little as 5 minutes time. However, there is some debate regarding the accuracy of rapid strep testing. (See this blog post by Dr. Robert Centor. Dr. Centor has studied strep pharyngitis extensively and often posts pearls regarding his experience and findings). The rapid testing can help to curb over-prescribing antibiotics for conditions clearly not warranting them. However, as we know, health care is not always so black and white. By the way, I always have the lab run a traditional throat culture when a rapid strep is negative due to the variability in rapid testing sensitivities. The rapid testing will not pick up the non-GAS bacteria.
I have seen some ill-appearing patients with a negative rapid strep throat ultimately have non-group A strep grow on a culture. I typically treated these patients with antibiotics upon examination and have seen them improve and have no sequella as a result. One of my most memorable cases of pharyngitis was a young ill-appearing adult ultimately diagnosed with Lemierre’s syndrome (with a negative rapid strep test). Lemierre’s syndrome is usually caused by the anaerobic bacterium Fusobacterium necrophorum, lead to a clot formation in the jugular vein, possibly leading to thrombosis and sepsis. This patient was ultimately hospitalized and recovered well but was required to be on blood thinners for a certain amount of time to avoid further clot formation.
Of course this was the exception to routine pharyngitis. However, if a patient is looking toxic or continues to complain of an increasing sore throat, don’t just write it off as viral. It warrants further and complete investigation to rule out the more serious causes.
Here is a differential diagnosis list for pharyngitis (partially from UpToDate):
- Group A Streptococcus
- Non-group A Streptococcus
- Fusobacterium necrophorum
- Infectious mononucleosis
- Primary HIV
- Neisseria gonorrohoeae
- Mycoplasma pneumoniae
- Chlamydophila pneumoniae
- Corynebacterium diptheriae
- Arcanobacterium haemolyticum
- Rhinovirus (post nasal drip)
- Gastroesophageal reflux
- Tumors
There are many potential causes for pharyngitis and as clinicians it is always important to take a complete history, perform an examination, and order the correct diagnostic tests. While I was told to “not look for zebras,” if the clinical presentation does not make sense, then its time to delve deeper into the investigation and consider other causes.

